arXiv:2511.08812v1 Announce Type: new
Abstract: This pilot study compares per-lesion radiomics features of [68Ga]-DOTA FAPI-46 and [18F]-FDG PET/CT in non-small cell lung cancer (NSCLC) to explore complementary insights into intratumoral heterogeneity beyond conventional SUV metrics, aiming to enhance lesion characterization and clinical decision-making. A total of 28 PET/CT scans (14 [18F]-FDG and 14 [68Ga]-DOTA FAPI-46) were acquired for the initial staging of biopsy-confirmed NSCLC. A total of 81 co-localized lesions (lung: 21, mediastinal lymph nodes: 42, bone: 18) were segmented, with radiomics features extracted via PyRadiomics after IBSI-compliant preprocessing. Paired per-lesion comparisons used t-tests or Wilcoxon signed-rank tests with Benjamini-Hochberg FDR correction. Significant differences (adjusted P